Cell Migration through Extracellular Matrix
نویسندگان
چکیده
منابع مشابه
Cell Migration through Extracellular Matrix
Every so often, a paper comes along that brings clarity to an issue. Clarity is not necessarily a final resolution, but rather a conceptual framework for productively addressing that issue. Such a paper could be based on a breakthrough discovery, an intriguing observation, a flash of intuition , or a systematic analysis. An excellent example of the latter is in this issue of The Journal of Cell...
متن کاملThe extracellular matrix and cell migration.
As we know all too well, pancreatic cancer has a very poor prognosis largely due to its early tendency to invade, locally and distantly. Recently, scientists in the field have increasingly focused on the desmoplastic reaction, which is characteristic of most pancreatic cancers. This reaction is associated with proliferation of fibroblastic cells, sometimes outnumbering local tumor cells, and co...
متن کاملCell Migration through Extracellular Matrix: Membrane-Type Metalloproteinases Make the Way
Every so often, a paper comes along that brings clarity to an issue. Clarity is not necessarily a final resolution, but rather a conceptual framework for productively addressing that issue. Such a paper could be based on a breakthrough discovery, an intriguing observation, a flash of intuition , or a systematic analysis. An excellent example of the latter is in this issue of The Journal of Cell...
متن کاملBreast tumor cells transendothelial migration induces endothelial cell anoikis through extracellular matrix degradation.
Mutual interactions between human breast cancer cells and endothelial cells were studied in a model mimicking tumor cell intravasation. MDA-MB-231 tumor cells and human umbilical vein endothelial cells (HUVEC) were cocultured on opposite sides of a Transwell filter allowing tumor cell contacts with the basement membrane of the HUVEC forming endothelium and tumor cell transendothelial migration....
متن کاملBves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition
Directional cell movement is universally required for tissue morphogenesis. Although it is known that cell/matrix interactions are essential for directional movement in heart development, the mechanisms governing these interactions require elucidation. Here we demonstrate that a novel protein/protein interaction between blood vessel epicardial substance (Bves) and N-myc downstream regulated gen...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2000
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.149.6.1167